Ru Rong Ji Lab

The main goal of the lab is to identify novel molecular and cellular mechanisms that underlie the genesis of chronic pain.

Ru rong ji lab. Ru-Rong Ji Lab, Duke University. Martini joined the LaFerla lab in 15, to study the relevance of inflammatory and immune responses in the progression of Alzheimer’s disease. Available in PMC 14 November 12.

Ru-Rong Ji, PhD Professor Departments of Anesthesiology, Cell Biology, and Neurobiology Director of Sensory Plasticity and Pain Research Laboratory Co-Director of Center for Translational Pain Medicine Ji lab studies molecular and cellular mechanisms of chronic pain using mouse models, electrophysiology, and cell biology assays. Currently he is a Distinguished Professor of Duke University and Co-Director of Center for Translational Pain Medicine. Ru-rong.ji@duke.edu Chronic pain is a major health problem in the US, affecting 100 million Americans.

Here, they address the question of how miRNAs might excite nociceptors via TLR7. Ru-Rong Ji, PhD, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, , USA. Male mice were purchased from The Jackson Laboratory and maintained at Duke.

Pharmacology & Cancer Biology Lab:. Distinguished Professor of Anesthesiology, in the School of Medicine. During her Ph.D., she was a visiting scholar at Duke University, under the supervision of Dr.

I received my M.S. Ji received his B.S. Eight interdisciplinary research teams at Duke have been selected to receive the 15-16 Duke Institute for Brain Sciences (DIBS) Research Incubator Awards (five new awards and three continuation awards).

Chul-Kyu Park,1 Ning Lü,1 Zhen-Zhong Xu,1 Tong Liu,1 Charles N. 1 Department of Anesthesiology, Duke University Medical Center, Durham, NC , USA.;. The long-term goal of the lab is to identify molecular and cellular mechanisms that underlie the genesis of chronic pain and, furthermore, to develop novel pain therapeutics that can target these mechanisms.

This led Ji to the lab of Yong-Hui Jiang, also at Duke, who had recently created genetically engineered mice lacking SHANK3;. Ru-Rong Ji’s lab has previously defined the pivotal role of TLRs in pain (Liu et al., 12). There are at least 30 different kinds of TRP, specialized to sense pain, itch, heat, cold, and other sensations and turn them into signals to the brain, said Ru-Rong Ji, Ph.D., a university distinguished professor of anesthesiology in the Duke School of Medicine who co-authored the study.

They have uncovered programmed cell death ligand-1 (PD-L1) as an endogenous inhibitor of acute and chronic pain. Liam Lewis - T32 Grant Funded 5T32GM Departmental Affiliation:. Serhan,2and Ru-Rong Ji1 1Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Ru-Rong Ji’s profile, publications, research topics, and co-authors. Qingqing Wang's lab at Zhejiang University, China. Prior to joining Duke, the main focus of my undergraduate research was autoimmune diseases.

The finding that the miRNA let-7b can rapidly activate nociceptors and induce pain via a pathway involving TLR7 and TRPA1 is astounding. However, our understanding of sexual dimorphism in CIPN remains unclear. Ru-Rong Ji, PhD, is the chief of pain research within Duke Anesthesiology, co-director of the Center for Translational Pain Medicine, and a professor of anesthesiology and neurobiology.

I received a BS in Biochemistry from Stony Brook University in 09. Third Year Mentor - Anesthesiology, Surgery, and Environmental Physiology Study Program (ASEP). 2 Department of Neurobiology, Duke University Medical Center, Durham, NC , USA.;.

In Biology at Nanjing University in China and received his Ph.D. Bo Tao from Johns Hopkins University joined Wu lab as a Research Assistant. As a first-year student, I'm currently doing my rotation in Dr.

The long-term goal of the lab is to identify molecular and cellular. He has been named as a Distinguished Professor of Duke University. Key Laboratory of Neuroregeneration of Jiangsu and the Ministry of Education, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, , China.

Briana Davis - T32 Grant Funded 5T32GM Departmental Affiliation:. Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center, Cincinnati, OH, , USA. The Ji lab is always recruiting talented postdoctoral fellows, visiting scholars, graduate students, and undergraduate students.

Ru-Rong Ji 1 , Zhen-Zhong Xu 1 , Yong-Jing Gao 2 Affiliations 1 Departments of Anesthesiology and Neurobiology, Duke University Medical Center, 595 LaSalle Street, Durham, North Carolina , USA. “We’re also interested to know if targeting this miRNA would be a way to alleviate pain.” The study was supported by NIH grants R01-DE, R01-DE, and NS to Ru-Rong Ji and R21-NS985 to Zhen-Zhong Xu. In Biology from San Diego State University, and my B.S.

Ru-rong.ji@duke.edu Injury/insult Arthritis, nerve injury, cancer treatment Non-neuronal cells Immune and glial cells Other cells Nociceptors Pain modulation. Ru-Rong Ji Lab, Duk Once hailed as a breakthrough in cancer treatment, immunotherapies are now raising concerns as doctors note new side effects like severe allergic reactions, acute-onset diabetes and heart damage. Molecular Genetics & Microbiology Lab:.

3 Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science. Alexander Chamessian 1, ;. I stayed in Dr.

Chronic pain is a major health problem in the US, affecting 100 million Americans. Liu was supported by grants from National Natural Science Foundation of China ( and. Nat Rev Drug Discov.

A nesthesiology ’s articles are made freely accessible to all readers, for personal use only, 6 months from the cover date of the issue. Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 0032, China. Currently, I am pursuing my PhD jointly with Dr Ru-Rong Ji in the Pain Signaling and Sensory Plasticity Laboratory and Dr Thomas Van de Ven in the Translational Pain Research Laboratory EDUCATION:.

Ru Rong Ji, PhD, of the department of anesthesiology at Duke University School of Medicine, and his team conduct molecular, cellular and electrophysiological studies in human dorsal root ganglion (DRG) neurons. Chronic pain is a major health problem in the US, affecting 100 million Americans. From an evolutionary perspective, sensing danger is.

During that time, she also worked at Duke University, as a visiting scholar, under the supervision of Dr. Brigham and Women's Hospital Department of Anesthesiology, Perioperative and Pain Medicine 75 Francis Street Boston, MA :. Ru-Rong Ji Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts , USA See all articles by this author.

15-16 new awards include Warren Grill (Biomedical Engineering), Ru-Rong Ji (Anesthesiology), Nandan Lad (Surgery) for their project on. Interested candidates should email their CV, a brief statement of interests, and a list of three references to Dr. Volume 133, Issue 4.

We employ a multidisciplinary approach that covers in vitro, ex vivo, and in vivo electrophysiology, cell biology of glial cells, immune cells, and cancer cells, transgenic mice, and mouse behaviors of various sensory. At UCI, Alessandra is studying the relevance of inflammatory and immune responses in the progression of Alzheimer’s disease. 3 Department of Anesthesiology, Duke University Medical Center, Durham, NC , USA.;.

Affiliations 1 Department of Anesthesiology, Duke University Medical Center, Durham, NC , USA. Ji was curious to see if the mice also had changes in pain perception, just like humans without the gene do. Ouyang Chen Departmental Affiliation:.

However, synaptic mechanisms by which IL-17 regulates pain transmission are unknown. I then came to Duke Med to begin my medical education in 10. In the lab, they use human DRG tissue to study gene expression in human sensory neurons and test novel pain therapeutics.

Pain is notoriously difficult to measure, but Ji said the new molecule may serve as a biomarker for pain. Ji gave a seminar on "Glial control of synaptic transmission and pain". Here we report that glia-produced IL-17 suppresses inhibitory synaptic transmission in spinal cord pain circuit and drives chemotherapy-induced neuropathic pain.

In this study, we examined the role of TLR9 in CIPN induced by paclitaxel in WT and Tlr9 mutant mice of both sexes. Chemotherapy-induced peripheral neuropathy (CIPN) remains a pressing clinical problem;. Tong Liu, 1, 2, 5 Qingjian Han, 1, 5 Gang Chen, 1 Ya Huang, 2 Lin-Xia Zhao, 3 Temugin Berta, 1 Yong-Jing Gao, 3 and Ru-Rong Ji 1, 4.

-- Once hailed as a breakthrough in cancer treatment, immunotherapies are now raising concerns as doctors note new side effects like severe. Ru-Rong Ji and colleagues have reported a method for treating pain intended to help treat inflammatory pain, neuropathic pain, and cancer pain. All animal procedures were conducted in accordance with the NIH’s Guide for the Care and Use of Laboratory Animals (National Academies Press, 11).

Ru-Rong Ji from Duke University Medical Center. Ru-Rong Ji, PhD Associate Professor of Anaesthesia, Harvard Medical School. NIH Public Access Author Manuscript Nat Rev Drug Discov.

Ru-Rong Ji Sensory neurons are activated by physical and chemical stimuli, eliciting sensations such as temperature, touch, pain, and itch. I joined the Knight Lab in 15, and I work in the wet lab where I assist our talented team in preparing samples for NGS applications. Duke University Medical Center, Durham, North Carolina.

Ru-Rong Ji, PhDProfessor and Co-Director Before joining Duke University, he was a faculty at Harvard Medical School (1998-12). From the Jackson Laboratory and maintained at the Duke University Animal Facility. Ru-Rong Ji, PhD, is distinguished professor and chief of pain research at Duke University Medical Center in Durham, North Carolina, US.

Serhan,2 and Ru-Rong Ji1 1Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, and 2Center for Experimental Therapeutics and Reperfusion Injury, Harvard Institutes of Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s. Duke University Medical Center. Ru-Rong Ji is a professor of Anesthesiology and Neurobiology, Chief of Pain Research at the Duke University Medical Center.

4 Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical. Address correspondence to Dr. This is the second in a series of Forum interviews with PRF’s eight new science advisors for 14-15.

Chul-Kyu Park,1Zhen-Zhong Xu,1Tong Liu,1Ning Lü,1Charles N. Temugin Berta 1 *, Tong Liu 1, Yen-Chin Liu 1, 2, Zhen-Zhong Xu 1, Ru-Rong Ji 1 1 Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA , USA. Here, I study neuron-cancer interaction as well as how cancer immunotherapy affects pain sensory.

And NS479 to R.-R.Ji. I am most interested in human-microbe interactions, especially in regard to the gut-brain axis. Long-Jun Wu invited and hosted the visit of Dr.

Ru-Rong Ji Lab, Duke University Once hailed as a breakthrough in cancer treatment, immunotherapies are now raising concerns as doctors note new side effects like. 2 Department of Neurobiology, Duke University Medical Center, Durham, NC , USA.;. The proinflammatory cytokine Interleukin-17 (IL-17) is produced mainly by Th17 cells and has been implicated in pain regulation.

Emerging studies indicate a sex-dimorphic role of Toll-like receptor 4 (TLR4) in driving neuropathic pain. Find a Researcher Ru-Rong Ji, PhD. Published in final edited form as:.

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From Saint Mary’s College of California. Her research focused on spinal cord injury neuroinflammation and pro-resolution mechanisms. The checkpoint inhibitory protein PD-L1 inhibited acute inflammatory pain.

CHICAGO - The American Society of Anesthesiologists (ASA) today presented Ru-Rong Ji, Ph.D., with its Excellence in Research Award in recognition of his extensive research career focused on.